Laura Niklason developed working lungs in the laboratory of stripping the cells from rat lung and Primátor of the remaining structure with fresh Zellen.Don Ingber creates a "lungs on a chip" that mimics the chemistry and mechanics of the lungs work and could be used for drug testing.
Copyright © 2010 national public radio ®.For only personal, non commercial Gebrauch.finden see "Terms and conditions". for other uses, permission required.IRA FLATOW, host:
Are from NPR SCIENCE Friday, listen. I am Ira Flatow.
Organ transplant patients spend months if not years, waiting for the right organ of the correct Spender.Laut US organ procurement and transplantation network, over 108,000 people waiting right now organs: heart, lungs, kidneys, liver.All patients alle-and all of you, 14,000, waited more than five years.
But what if instead of waiting for someone to free another body, could you a "new" in the lab, with your own patient cells? This is of course impossible now has but my next guest work a significant step towards him by the construction of lung, building work lungs in a Labor.Und how you did it is quite a story, and the research appears this week in the journal Science.
Laura Niklason is Professor of anesthesia and biomedical engineering from Yale University in New Haven, Connecticut.Sie connects us by Telefon.Willkommen on SCIENCE Friday, Dr. Niklason.
Dr. LAURA NIKLASON (Professor, Anesthesiology & biomedical technology, Yale University): it is great here to sein.Vielen thanks.
FLATOW: We have a little video of - build the Lunge.Sie actually built, the lungs in the Labor.Geben you us the steps of what you have done.
Dr. NIKLASON: Well, we started taking of lung of adult rats and take out carefully wash away the cells that were in the lungs, so what was left behind the framework or the skeleton of lung, consisting as collagen and elastin proteins, extracellular matrix was really.
We then deferred cells in the framework back in the skeleton and cultivated the lungs in a bioreactor that really mimics some environment of the foetus as the fetus grows.After a week we put culture, some of these lungs again in different rats and we saw that you acted at least for a few hours.
FLATOW: So you basically washed all the cells and the structure left the lungs, and put your sort of rebuilt the uterus, in effect, again where originated the lungs.
Dr. NIKLASON: Yes, we haben.Wir worked several years bioreactor to create some of the aspects of uterus, including perfusion mimic nutrient medium by the lungs würde.Und we also equipped, so that might coax lungs breathing bioreactors you inhale and exhale medium much nutrient as do the fetal lung during development.
FLATOW: how the cells have now, and there are many different types of cells in one lung, right?
Dr. NIKLASON: Correct.
FLATOW: How did you wherever you go and what to do?
Dr. NIKLASON: Well, that's one of the surprising and remarkable results of some of this work is that we do not expect to find, but we found when we took cells from a healthy lung that the skeleton that left behind actually alot of zip codes in it hatte.Es was actually a lot of information about what types of cells where you want to land.
And we only discovered this setting mixes of different types of cells in the matrix and saw then about a week Später.Was we found that most of the cells to their correct spots went as had little homing signals.
FLATOW: Wow. is our 1-800-989-8255 Nummer.Wir talk about creating a Labor.Sie lungs can also tweet
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